HB-EGF, mouse recombinant | 4267

HB-EGF is an EGF related growth factor which signals via the EGF receptor, and stimulates the proliferation of SMC (smooth muscle cells), fibroblasts, epithelial cells and keratinocytes. HB-EGF is expressed in various cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes and particular tumor cells. HB-EGF’s ability to explicitly bind heparin and heparin sulfate proteoglycans is dissimilar from other EGF-like molecules, and might be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells.

4267 | HB-EGF mouse recombinant DataSheet

Biomolecule/Target: HB-EGF

Synonyms: Heparin-binding EGF-like growth factor, DTR, HEGFL, diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor), DTSF, proheparin-binding epidermal growth factor-like growth factor.

Alternates names: IBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.

Taglines: EGF like growth factor involved in cell proliferation

NCBI Gene ID #: 3484

NCBI Gene Symbol: IBP1

Gene Source: Mouse

Accession #: P08833

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: The ED as determined by its ability to inhibit IGF-I induced proliferation of NUC-1 cells is ~100 ng/ml.

Results: ~100 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 28.8 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized with no additives

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A