HBB polyclonal Antibody | BS8007

HBB polyclonal Antibody | BS8007 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Hemoglobin (Hgb) is coupled to four iron-binding,methene-linked tetrapyrrole rings (heme) . The α (16p13.3; 5'-ζ-pseudoζ-pseudoα2-pseudoα1-α2-α1-θ1-3') and β (11p15.4) globin loci determine the basic hemoglobin structure.The globin portion of Hgb consists of twoαchains and two β chains arranged in pairsforming a tetramer. Each of the four globin chainscovalently associates with a heme group. The bonds between α and β chains are weaker than between similar globin chains, therebyforming a cleavage plane that is important for oxygen binding and release. High affinityfor oxygen occurs upon relaxation of theα1-β2 cleavage plane. When the twoα1-β2 interfaces are closely bound, hemoglobin has a lowaffinityfor oxygen. Hb A,which containstwo α chains plustwo β chains,comprises 97% of totalcirculating hemoglobin. The remaining 3% of totalcirculating hemoglobin iscomprised of Hb A-2,which consists of twoαchains plustwo δ chains, and fetal hemoglobin (Hb F),which consists of two α chainstogetherwith two γ chains.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HBB polyclonal Antibody detects endogenous levels of HBB protein.

Molecular Weight: ~ 16 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain; Cleaved into the following 2 chains:LVV-hemorphin-7; Spinorphin

Immunogen: Recombinant full length Human HBB.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: