HCAR2 polyclonal Antibody | BS72723

HCAR2 polyclonal Antibody | BS72723 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D) -beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G (i) -protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HCAR2 polyclonal Antibody detects endogenous levels of HCAR2 protein.

Molecular Weight: 42kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: N/A

Immunogen: A synthetic peptide of human HCAR2

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: