HCLS1 polyclonal Antibody | BS6914

HCLS1 polyclonal Antibody | BS6914 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin. HS1 contains four cortactin repeats and a single SH3 domain. This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse. Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1. HS1 also plays an important role in platelet activation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HCLS1 polyclonal Antibody detects endogenous levels of HCLS1 protein.

Molecular Weight: ~ 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1 LckBP1; p75; HCLS1; HS1

Immunogen: Recombinant full length Human HCLS1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: