HCN1 Antibody (C-term) [APR12349G]

HCN1 Antibody (C-term) [APR12349G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 860-889 amino acids from the C-terminal region of human HCN1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 98796

Clone: Polyclonal

Gene Name: HCN1

Gene ID: 348980

Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084) . Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) . May mediate responses to sour stimuli.

Summary: Tissue Location: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Brain cyclic nucleotide-gated channel 1, BCNG-1, HCN1, BCNG1