HDAC, EGFR & HER2 inhibitor | B2933

HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC₅₀ values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits the growth of different cell lines such as HCC827, H358, H460 with IC₅₀ values of 0.93 μM, 0.71 μM, 0.90 μM respectively.

HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC₅₀ values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits the growth of different cell lines such as HCC827, H358, H460 with IC₅₀ values of 0.93 μM, 0.71 μM, 0.90 μM respectively.

B2933 | HDAC, EGFR & HER2 inhibitor DataSheet

Alternate Name/Synonyms: 7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide; 7-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide

Appearance: Solid

Formulation:

CAS Number: 1012054-55-5

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₂H₂₄ClFN₄O₄

Molecular Weight: 462.9

Cell-Permeable?: True

Purity: 95%

Solubilities: Soluble in DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An HDAC, EGFR, and HER2 Inhibitor

MDL Number:

PubChem CID:

SMILES: O=C(NO)CCCCCCOC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC

InChi: InChI=1S/C22H24ClFN4O4/c1-31-19-12-18-15(11-20(19)32-9-5-3-2-4-6-21(29)28-30)22(26-13-25-18)27-14-7-8-17(24)16(23)10-14/h7-8,10-13,30H,2-6,9H2,1H3,(H,28,29)(H,25,26,27)

InChi Key: RQYVKBOWLRVISJ-UHFFFAOYSA-N