HDAC4 (N-terminus) monoclonal Antibody | MB0041

HDAC4 (N-terminus) monoclonal Antibody | MB0041 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB ICC

Application Range: WB: 1:1000 ICC: 1:50~200

Background: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, p300/CBP, PCAF (p300/CBPassociated factor), HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of HDAC4 (N-terminus) and does not cross-react with related proteins

Molecular Weight: Predicted band size:120KDa Observed band size:130KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Histone deacetylase 4; HD4; HDAC4; KIAA0288

Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human HDAC4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: