HDAC8 polyclonal Antibody | BS90623

HDAC8 polyclonal Antibody | BS90623 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IP FC

Application Range: WB:1:1,000-1:2,000 FC:1:50-1:100

Background: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: HDAC8 polyclonal Antibody detects endogenous levels of HDAC8 protein.

Molecular Weight: 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HD8, HDAC8, CDA07, CDLS5, HD 8, HD8, HDAC 8, Hdac8, HDAC8, HDACL 1, HDACL1, Histone deacetylase 8, Histone deacetylase like 1, MRXS6, RPD 3, RPD3, WTS,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: