Hemagglutinin Antibody [4E11E1] | PM-4671

Hemagglutinin Antibody [4E11E1] | PM-4671 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Virus

Homology: N/A

Immunogen: Recombinant protein corresponding to amino acids 17 - 338 of H5 HA1.

Research Area: Infectious Disease

Tested Application: E, WB

Application: Hemagglutinin antibody can be used for detection of H5 HA1 by Western blot at 2.5 μg/mL. Hemagglutinin antibody also specifically recognizes Avian H5N1 influenza virus at 2 μg/mL.

Specificiy: N/A

Positive Control 1: Cat. No. 95-101 - H5 Hemagglutinin HA1 Recombinant Protein

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Hemagglutinin Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Clonality: Monoclonal

Clone: 4E11E1

Isotype: IgG1, IgG2b

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Hemagglutinin Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: Hemagglutinin monoclonal antibody can be stored at -20˚C, stable for one year.

Alternate Name: Hemagglutinin Antibody [4E11E1] :

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Hemagglutinin Monoclonal Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, but it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with host cell surface proteins containing oligosaccharides with terminal sialyl residues. Its extracellular region has two domains (HA1 and HA2) ; HA1 is cleaved from the main hemagglutinin protein by the host immune system. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. This more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in Southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the efficiency of this type of transmission is low. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.