337

HemogloBind™ Trial Kit - 5 ml Hemoglobind™ & 5 Preps of NuGel-HemogloBind™

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SKU:
337-337-HB145K-GEN
Availability:
IN STOCK
NULL457.00

Description

HemogloBind™ was derived from a family of acid-alcohol elastomeric co-polymers. These polymers are synthesized to have separation characteristics like salts and solvents, but with the mechanical advantages: simple removal of the bound macromolecules with no solute carryover, and adaptability to filtration, centrifugation, and automation. HemogloBind™ comes from a class of solid-phase, or surface-based, elastomeric poly-electrolytic surfaces that bind proteins through an empirically derived chemistry combining elements of polymer composition, cross-linking architecture and charge properties. HemogloBind™ is engineered for a high degree of selectivity and does not cross react with most common serum components, making it an excellent tool in numerous applications. These include analytical protocols where optical interference is problematic, such as bilirubin analysis and bulk serum clarification. Hemoglobin variants, as in thalassemia, bind with differential affinity towards HemogloBind™. For purification and/or analysis of hemoglobin, a modest elevation in pH will facilitate desorption of hemoglobin bound to HemogloBind™.

Characteristics of HemogloBind™ Hemoglobin Removal and Capture
  • Has a high degree of specificity for hemoglobin binding up to 10 mg/ml
  • Applications in blood substitutes, enzyme recovery and analytical interferences
  • Removes hemoglobin from any species including human, sheep, bovine, goat, etc
  • Removes hemoglobin from organs, tissues.
  • Hemoglobin removal from red blood cell lysate for proteomics and biomarker drug discovery
  • The flow through fractions retain their enzymatic and biological activity
  • The flow through fractions are compatible with LC-MS, activity based protein profiling and proteomic research.
NuGel™ HemogloBind™ has similar separations performance but is supplied as a dry powder, rather than as a liquid suspension. NuGel-Hemoglobind™ is reengineered for increased stability. It is based on NuGel™ silica (50 microns in size, 1000Å) covalently bound to elastomeric polyelectrolytes. It binds >95% of hemoglobin from blood.
 
Characteristics of NuGel-Hemoglobind™ - Hemoglobin Capture Reagent From Blood and Hemolyzed Serum with NuGel™ Matrix
  • Has a high degree of specificity for hemoglobin binding up to 10 mg/ml
  • Removes hemoglobin from any species including human, mouse, rat, sheep, bovine, goat, etc
  • Removes hemoglobin from organs, tissues.
  • Hemoglobin removal from red blood cell lysate for proteomics and biomarker drug discovery
  • The flow through fractions(hemoglobin depleted) retain their enzymatic and biological activity
  • The flow through fractions(hemoglobin depleted) is compatible with LC-MS, activity based protein profiling and proteomic studies.
  • Linearly scaleable up or down. Easy high throughput automation.
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