HER2 Antibody [HRB2/258] | 33-123

HER2 Antibody [HRB2/258] | 33-123 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Rat

Homology: N/A

Immunogen: Recombinant human protein was used as the immunogen for this ErbB2 antibody. (1)

Research Area: Cancer

Tested Application: WB, Flow, IF

Application: Flow Cytometry: 0.5-1 ug/million cells
IF: 0.5-1 ug/ml
Variations in protocols, secondaries and substrates may require the antibody to be titered for optimal performance.

1. This ErbB2 antibody binds to the extracellular/cell surface region of the protein.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Protein G purified

Clonality: Monoclonal

Clone: HRB2/258

Isotype: IgG2a, kappa

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Concentration: 0.2 mg/mL

Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.

Alternate Name: erbB-2 Antibody: NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu, MLN19, NEU, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein

User Note: Optimal dilutions for each application to be determined by the researcher

BACKGROUND: This antibody recognizes a protein of 185kDa, which is identified as HER2 / ErbB2. Its epitope is localized in the extracellular domain. ErbB2 is a member of the EGFR family. This antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.