HER3 (Phospho-Y1222) polyclonal Antibody | BS64529

HER3 (Phospho-Y1222) polyclonal Antibody | BS64529 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HER3 (Phospho-Y1222)  polyclonal Antibody detects endogenous levels of HER3 protein only when phosphorylated at Tyr1222.

Molecular Weight: ~ 220 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ERBB3; ERBB3 protein; erbB3 S; ERBB3; Glial growth factor receptor; HER-3; HER3; LCCS2; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c ErbB 3;

Immunogen: Synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyrosine 1222.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Examples of Crosstalk Between Post-translational Modifications,