Herbimycin A | 2748

Herbimycin A is an ansamycin antibiotic isolated from Streptomyces sp. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2. Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity. It also inhibits angiogenesis in a rat retinopathy model.

Herbimycin A is an ansamycin antibiotic isolated from Streptomyces sp. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2. Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity. It also inhibits angiogenesis in a rat retinopathy model.

2748 | Herbimycin A DataSheet

Alternate Name/Synonyms: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin

Appearance: Yellow lyophilized solid

Formulation: N/A

CAS Number: 70563-58-5

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₄₂N₂O₉

Molecular Weight: 574.7

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 6 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent protein tyrosine kinase (PTK) inhibitor

MDL Number: MFCD00151702

PubChem CID: 6436247

SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC

InChi: InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9+,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1

InChi Key: MCAHMSDENAOJFZ-GDYSMBPZSA-N