HG-10-012-01 | 2604

Brain-permeable. HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC₅₀ values are ~20.3 nM and ~ 3.2 nM, respectively). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells. May be a useful tool for Parkinson’s Disease research.

HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC₅₀ values are ~20.3 nM and ~ 3.2 nM, respectively). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in cells.

2604 | HG-10-012-01 DataSheet

Alternate Name/Synonyms: [4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1351758-81-0

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₂₀ClN₅O₃

Molecular Weight: 377.83

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A wild-type LRRK2 and the G2019S mutant inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(N1CCOCC1)C(C=C2)=CC(OC)=C2NC3=NC=C(Cl)C(NC)=N3

InChi: InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)

InChi Key: YEVOZZZLKJKCCD-UHFFFAOYSA-N