HIPK2 polyclonal Antibody | BS60320

HIPK2 polyclonal Antibody | BS60320 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The Homeodomain-Interacting Protein Kinase (HIPK) family, which includes HIPK1, HIPK2, HIPK3, contains a conserved protein kinase domain as well as a separate domain that interacts with homeoproteins. HIPK2, the most highly characterized family member, is thought to act as a co-repressor of homeodomain transcription factors as HIPK2 has been shown to enhance the DNA binding of the NK-3 homeoprotein in vitro. It is regulated by a posttranslational modification of a ubiquitin-like protein, SUMO-1, via covalent bonding to a lysine residue on HIPK2. This is similar to the binding of SUMO-1 to PML and Sp100. The conjugation of SUMO-1 is thought to direct each of these proteins to nuclear bodies (NBs), which appear to play a role in autoimmunity and viral protection. HIPK2 is the first protein kinase to be directed to nuclear bodies in response to ubiquitin-like modification.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HIPK2 polyclonal Antibody detects endogenous levels of HIPK2 protein.

Molecular Weight: ~ 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Homeodomain-interacting protein kinase 2; hHIPk2

Immunogen: A synthetic peptide corresponding to residues in Human HIPK2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: