HIPK3 Polyclonal Antibody | E-AB-19326

HIPK3 Polyclonal Antibody | E-AB-19326 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Androgen receptor interacting nuclear protein kinase, Androgen receptor-interacting nuclear protein kinase, ANPK, DYRK6, Fas interacting serine/threonine protein kinase, Fas-interacting serine/threonine-protein kinase, FIST, FIST3, Hipk3, HIPK3, homeodomain interacting protein kinase 3, Homeodomain-interacting protein kinase 3, Homolog of protein kinase YAK1, PKY, RP24 297H17.5, YAK1

Application: IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction

Background: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Concentration: 0.6 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human HIPK3

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A