HIRA (Ab-555) polyclonal Antibody | BS65148

HIRA (Ab-555) polyclonal Antibody | BS65148 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB,IHC-p,IF/ICC,ELISA

Application Range: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Background: histone cell cycle regulator (HIRA) Homo sapiens This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008],

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Phospho-HIRA (T555) Polyclonal Antibody detects endogenous levels of HIRA protein only when phosphorylated at T555.

Molecular Weight: /

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HIRA; DGCR1; HIR; TUPLE1; Protein HIRA; TUP1-like enhancer of split protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human HIRA around the phosphorylation site of Thr555. AA range:521-570

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pathway: Phospholipase Signaling,Translational Contral elF4 and p70 S6 Kinase,Signaling Pathways Activating p38 MAP KinaseInsulin &Glucose Signaling,