Histone H4 (Acetyl-K12) polyclonal Antibody | BS74026

Histone H4 (Acetyl-K12) polyclonal Antibody | BS74026 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Other (Wide Range)

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Histone H4 (Acetyl-K12) polyclonal Antibody detects endogenous levels of Histone H4 protein only when acetylated at Lys12.

Molecular Weight: Refer to Figures

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: N/A

Immunogen: A synthetic acetylated peptide around K12 of human Histone H4

Conjugate: Unconjugated

Modification: Acetylated

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: