HLA-DMA Antibody | 22-557

HLA-DMA Antibody | 22-557 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-233 of human HLA-DMA (NP_006111.2) .

Research Area: Immunology

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: A-431

Positive Control 2: Jurkat

Positive Control 3: HeLa

Positive Control 4: Mouse lung

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 35kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: D6S222E, DMA, HLADM, RING6, HLA class II histocompatibility antigen, DM alpha chain, MHC class II antigen DMA, class II histocompatibility antigen, M alpha chain, really interesting new gene 6 protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB) , both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.