HLA-DMB Polyclonal Antibody | E-AB-52583

HLA-DMB Polyclonal Antibody | E-AB-52583 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: class II antigen HLA-DM beta chain, class II histocompatibility antigen, Class II histocompatibility antigen M beta chain, D6S221E, DMB, HLA class II histocompatibility antigen DM beta chain, HLA-DM histocompatibility type, beta chain, M beta chain, Major histocompatibility complex class II DM beta, MHC class II antigen DMB, MHC class II antigen HLA DM beta chain, MHC class II HLA DMB, OTTHUMP00000029257, Really interesting new gene 7 protein, RING 7, RING7

Application: WB, IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Immunology

Background: HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Concentration: 1.38 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human HLA-DMB

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 29 kDa

Molecular Weight(Observed): Refer to figures