HLCL-61 hydrochloride | B1209

HLCL-61 is a potent and selective PRMT5 (potent arginine methyltransferase 5) inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. In vitro data shows HLCL-61 effectively inhibits symmetric arginine demethylation of histones H3 and H4 in AML samples. HLCL-61 treatment of cells showed decrease in cell vitality and effective in apoptosis promotion in MV-11 and THP-1 cells after 48 hours.

HLCL-61 is a potent and selective PRMT5 (potent arginine methyltransferase 5) inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. In vitro data shows HLCL-61 effectively inhibits symmetric arginine demethylation of histones H3 and H4 in AML samples. HLCL-61 treatment of cells showed decrease in cell vitality and effective in apoptosis promotion in MV-11 and THP-1 cells after 48 hours.

B1209 | HLCL-61 hydrochloride DataSheet

Alternate Name/Synonyms: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride

Appearance: Crystalline Solid

Formulation: N/A

CAS Number: 586395-74-6 (free base).

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₂₃H₂₅ClN₂O

Molecular Weight: 380.92

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective PRMT5(potent arginine methyltransferase 5) inhibitor

MDL Number: N/A

PubChem CID: 17208222

SMILES: CN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl

InChi: InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H

InChi Key: XYAVCNMZZKTEGR-UHFFFAOYSA-N