HMGB2 (K165) polyclonal Antibody | BS1967

HMGB2 (K165) polyclonal Antibody | BS1967 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the N κB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HMGB2 (K165) polyclonal Antibody detects endogenous levels of HMGB2 protein.

Molecular Weight: ~ 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: High mobility group (nonhistone chromosomal) protein 2; high mobility group box 2; High mobility group protein 2; High mobility group protein B2; high-mobility group (nonhistone chromosomal) protein 2; HMG 2; HMG B2; HMG-B2; HMG-2; HMG2; HMGB-2;

Immunogen: Synthetic peptide, corresponding to amino acids 136-180 of Human HMGB2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Immune Cell Signaling,Warburg Effect,Regulation of Microtubule Dynamics,T cell receptor signaling,Inhibition of Apoptosis,Insulin &Glucose Signaling,G Protein-coupled Receptors Signaling to MAPK Erk,MAPK Erk in Growth and Differentiation Pathway,Mitochondrial Control of Apoptosis,ErbB HER Signaling,