HNMT Antibody | 18-684

HNMT Antibody | 18-684 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human HNMT (NP_008826.1) .

Research Area: Neuroscience

Tested Application: WB, IF, IP

Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:100
IP: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: 22RV1

Positive Control 2: NCI-H460

Positive Control 3: HT-29

Positive Control 4: HepG2

Positive Control 5: HeLa

Positive Control 6: Mouse liver

Molecular Weight: Observed: 33kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: Histamine N-methyltransferase, HMT, HNMT

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: In mammals, histamine is metabolized by two major pathways: N (tau) -methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N (tau) -methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.