HOOK2 Antibody (N-term) [APR33212G]

HOOK2 Antibody (N-term) [APR33212G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HOOK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-197 amino acids from the N-terminal region of human HOOK2.

Cellular Localisation: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TMK6}. Golgi apparatus, trans-Golgi network. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036) . Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036, PubMed:32073997) . Often found in close association with microtubules (PubMed:17540036) . Localizes to the manchette in elongating spermatids (By similarity) . {ECO:0000250|UniProtKB:Q7TMK6, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:32073997}

Molecular Weight: 83207

Clone: Polyclonal

Gene Name: HOOK2

Gene ID: 29911

Function: Component of the FTS/Hook/FHIP complex (FHF complex) . The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) . Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Protein Hook homolog 2, h-hook2, hHK2, HOOK2