HPD polyclonal Antibody | BS8265

HPD polyclonal Antibody | BS8265 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Background: HPPD (4-hydroxyphenylpyruvate dioxygenase), also known as PPD, GLOD3 or HPD, is a 393 amino acid protein that belongs to the 4HPPD family and is involved in amino acid degradation. Existing as a homodimer, HPPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Defects in the gene encoding HPPD are the cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK), both of which are inborn errors of metabolism that are associated with a variety of symptoms, including mental retardation and seizures (associated with TYRO3) and hair and urine abnormalities (associated with HAWK) . The gene encoding HPPD maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HPD polyclonal Antibody detects endogenous levels of HPD protein.

Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; HPD; PPD

Immunogen: Recombinant full length Human HPD.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: