HPGD Antibody (C-term) [APR16708G]

HPGD Antibody (C-term) [APR16708G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HPGD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-212 amino acids from the C-terminal region of human HPGD.

Cellular Localisation: Cytoplasm.

Molecular Weight: 28977

Clone: Polyclonal

Gene Name: HPGD (HGNC:5154)

Gene ID: 3248

Function: Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable) . Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PubMed:15574495, PubMed:16828555, PubMed:8086429) . Catalyzes the NAD- dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PubMed:10837478) . Converts 11 (R) -HETE to 11-oxo-5, 8, 12, 14- (Z, Z, E, Z) - eicosatetraenoic acid (ETE) (PubMed:21916491) . Has hydroxylated docosahexaenoic acid metabolites as substrates (PubMed:25586183) . Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PubMed:16757471, PubMed:22844113) .

Summary: Tissue Location: Detected in colon epithelium (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:2000 WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: 15-hydroxyprostaglandin dehydrogenase [NAD (+) ], 15-PGDH, Prostaglandin dehydrogenase 1, HPGD, PGDH1