Description
HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC₅₀’s range from 0.2 to 6 µM for various cell-based assays.
HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC₅₀’s range from 0.2 to 6 µM for various cell-based assays.
Alternate Name/Synonyms: 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
Appearance: Yellow solid
Formulation: N/A
CAS Number: 599150-20-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₂₉NO₆ · XH₂O
Molecular Weight: 463.52
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~25 mg/ml) or EtOH (~25 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A potent Hedgehog signaling pathway inhibitor
MDL Number: MFCD17215941
PubChem CID: 71311904
SMILES: CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O
InChi: InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3;/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3;1H2
InChi Key: BOASXIAGFOONSK-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |