HPOB | B2832

HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human prostate adenocarcinoma, A549 lung adenocarcinoma, and U87 glioblastoma) cells in a concentration-dependent manner at 8 μM, 16 μM, or 32 μM, but does not induce cell death. HPOB causes accumulation of acetylated α-tubulin in these cells. HPOB enhances cell death induced by the anticancer drugs etoposide, doxorubicin and SAHA.

HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human prostate adenocarcinoma, A549 lung adenocarcinoma, and U87 glioblastoma) cells in a concentration-dependent manner at 8 μM, 16 μM, or 32 μM, but does not induce cell death. HPOB causes accumulation of acetylated α-tubulin in these cells. HPOB enhances cell death induced by the anticancer drugs etoposide, doxorubicin and SAHA.

B2832 | HPOB DataSheet

Alternate Name/Synonyms: N-hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide; 4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-Benzamide; 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1429651-50-2

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₇H₁₈N₂O₄

Molecular Weight: 314.34

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~10 mg/ml in DMF in 0, ~15 mg/ml in in Ethanol, ~20 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of HDAC6

MDL Number: MFCD27952937

PubChem CID: 71532921

SMILES: C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO

InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)

InChi Key: RFAZNTABYJYOAR-UHFFFAOYSA-N