HPR Antibody (Center) [APR03529G]

HPR Antibody (Center) [APR03529G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This HPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of human HPR.

Cellular Localisation: Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL) .

Molecular Weight: 39030

Clone: Polyclonal

Gene Name: HPR

Gene ID: 3250

Function: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I) -containing high-density lipoprotein (HDL) . This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Summary: Tissue Location: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:16000

Synonyms: Haptoglobin-related protein, HPR