HSD17B1 polyclonal Antibody | BS72641

HSD17B1 polyclonal Antibody | BS72641 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: 17b-hydroxysteroid dehydrogenase type 1 (17b-HSD) catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express 17b-HSD. Other tissues that express 17b-HSD include testis, placenta, uterus, prostate and adipose tissue. 17b-HSD functions as a homodimer and prefers NADP (H) over NAD (H) for oxidation and reduction. The gene encoding human 17b-HSD maps to chromosome 17q12-q21. The importance of 17b-HSD to estradiol production suggests the specific inhibition of 17b-HSD may aid in breast cancer therapy. Breast cancer patients with an amplification of 17b-HSD expression statistically have a worse outcome than those without. 17b-HSD amplification in tamoxifen-treated patients correlates to decreased breast cancer survival.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HSD17B1 polyclonal Antibody detects endogenous levels of HSD17B1 protein.

Molecular Weight: 35kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: EDH17B2;EDHB17;HSD17;SDR28C1

Immunogen: Recombinant protein of human HSD17B1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: