HSPB1 (phospho-S78) polyclonal Antibody | BS3629

HSPB1 (phospho-S78) polyclonal Antibody | BS3629 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC:1:50~1:200

Background: Hsp27, also referred to as the Estrogen-Regulated 24K protein and HSP28, is one of several small heat shock proteins (HSP) produced by all organisms studied. Hsp27 synthesis is induced by elevated temperature, as well as estrogen in hormone responsive cells. This protein is involved in stress resistance and actin organization. Interestingly, human HSP27 also shares greater than 50% homology with low molecular weight Drosophila HSP's and mammalian a-crystalline lens protein. Because of the estrogen-responsive nature of Hsp27, this protein has been studied extensively in human estrogen-responsive tissues such as cervix, endometrium and breast tissue. This work has led to the suggestion that Hsp27 may be a useful marker in classifying various hormone sensitive tumors.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HSP27 (A72) polyclonal Antibody detects endogenous levels of HSP27 protein.

Molecular Weight: ~ 27 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; HSPB1; HSP27; HSP28

Immunogen: Synthetic peptide, corresponding to amino acids 41-90 of Human HSP27.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Hypoxia Signaling,Warburg Effect,Translational Contral elF4 and p70 S6 Kinase,Insulin &Glucose Signaling,AMPK Signaling Pathway,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,