Human Beta-Catenin | P1626

Beta-catenin is a key downstream component of the canonical Wnt signaling pathway. β-catenin associates with E-cadherin and is involved in regulation of cell adhesion. Stimulation of Wnt pathway can trigger nuclear translocation of β‐catenin. Over expression of β-catenin occurs in various cancers such as colorectal, lung, malignant breast tumor, hepatocellular carcinoma and can be used as a tumor biomarker.

P1626 | Human Beta-Catenin DataSheet

Biomolecule/Target :

Synonyms: Catenin beta-1; CTNNB1; CTNNB

Alternates names: Catenin beta-1; CTNNB1; CTNNB

Taglines: A component of the Wnt signalling pathway

NCBI Gene ID #: 1499

NCBI Gene Symbol:

Gene Source: Human

Accession #: P35222-1, XP_016861227.1

Recombinant: TRUE

Source: E.coli

Purity by SDS-PAGE: ≥ 92% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level: < 0.1 EU/ug of the protein as determined by LAL method

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: The protein migrates as a ~100-110 kDa band in SDS-PAGE.

Concentration:

Appearance: Liquid

Physical form description:

Reconstitution Instructions:

Amino acid sequence: The target protein is expressed with the sequence (aa Met1-Leu781) of human Beta-Catenin protein fused to 6×His tag at the C-terminus.

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans