Human CellExp™ ACVR2B (Active), Human Recombinant | P1731

Activin A receptor type 2B (ACVR2B) is a constitutively active transmembrane serine/threonine kinase that forms a complex with type I activin receptors to transduce activin signaling. Activin signaling is responsible for regulating many physiological and pathological processes including neuronal differentiation and survival, hair follicle development, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis.

P1731 | Human CellExp ACVR2B (Active), Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: Activin A Receptor Type 2B; ACTR-IIB; ACTRIIB; HTX4

Alternates names: Activin A Receptor Type 2B; ACTR-IIB; ACTRIIB; HTX4

Taglines: Constitutively active receptor serine/threonine kinase that regulates many physiological processes

NCBI Gene ID #: 93

NCBI Gene Symbol:

Gene Source: Human

Accession #: Q13705

Recombinant: True

Source: Human Cells

Purity by SDS-PAGE: > 95% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level: < 1.0 EU per ug as determined by the LAL method

Activity (Specifications/test method): Immobilized Activin A at 5 ug/ml (100 ul/well) can bind Human ACVR2B. The ED50 of Human ACVR2B is 20.58 ng/ml

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 41.3 kDa calculated; 60 kDa observed

Concentration:

Appearance: Lyophilized protein

Physical form description: Lyophilized powder

Reconstitution Instructions:

Amino acid sequence: Ser 19 to Thr 134 with C-terminal Fc & 6xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans