Human CellExp™ ADIPOQ /Adiponectin /ACRP30, human recombinant | 7232

Adiponectin also referred to as GBP-28, APM1, ADIPOQ, ACDC and Acrp30, is a secreted protein which contains one C1q domain (commonly called the globular domain) and one collagen-like domain. Adiponectin / ADIPOQ is synthesized exclusively by adipocytes and secreted into plasma. ADIPOQ is important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Acrp30 Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway and may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

7232 | Human CellExp ADIPOQ /Adiponectin /ACRP30 human recombinant DataSheet

Biomolecule/Target: Adiponectin

Synonyms: ADIPOQ, Adiponectin, ACDC, ACRP30, APM1, GBP28

Alternates names: ADIPOQ, Adiponectin, ACDC, ACRP30, APM1, GBP28

Taglines: Involved in the control of fat metabolism and insulin sensitivity

NCBI Gene ID #: 1437

NCBI Gene Symbol: CSF2

Gene Source: Human

Accession #: P04141

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): Measured by its ability to induce TIMP-1 secretion by mouse macrophages. The ED50 for this effect is typically 2 - 10 µg/ml.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: The protein is fused with 6×His tag at the C-terminus, has a calculated MW of 25.4 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized from a 0.2 m filtered solution of 20 mM PB, 150 mM NaCl, pH7.4.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Amino acid sequence: N/A