Human CellExp™ BTN1A1 / Butyrophilin, Human Recombinant | P1261

Butyrophilin subfamily 1 member A1 (BTN1A1) is also known as BTN, which is a member of the immunoglobulin superfamily and the major protein, associated with fat droplets in the milk. BTN1A1 may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families. Furthermore, BTN1A1 regulates the amount of lipids and size of droplets expressed in milk and inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

P1261 | Human CellExp BTN1A1 / Butyrophilin Human Recombinant DataSheet

Biomolecule/Target: BTN1A1

Synonyms: BTN1A1, Butyrophilin, BTN

Alternates names: Proepithelin, PEPI, PC Cell-derived Growth Factor.

Taglines: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

NCBI Gene ID #: 2896

NCBI Gene Symbol: GRN

Gene Source: Human

Accession #: P28799

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per/g

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~74 kDa (observed due to glycosylation)

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: N/A

Amino acid sequence: Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional amino acids.