Human CellExp™ CD244/ 2B4/ SLAMF4, Fc Tag, Human Recombinant | P1305

Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contain two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

P1305 | Human CellExp CD244/ 2B4/ SLAMF4 Fc Tag Human Recombinant DataSheet

Biomolecule/Target: CD244

Synonyms: CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4

Alternates names: Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B)

Taglines: Modulates receptor-ligand interactions to enhance leukocyte activation

NCBI Gene ID #: 7033

NCBI Gene Symbol: TFF3

Gene Source: Human

Accession #: Q07654

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Determined by its ability to chemoattract human MCF-7 cells using a concentration 1.0-10.0 ng/ml.

Results: 1.0-10.0 ng/ml.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 13.2 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Reconstitution Instructions: Reconstitute in sterile 18 M-cm HO at not less than 100 µg/ml. Reconstituted TFF3 should be stored in working aliquots at -20°C.

Amino acid sequence: EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF