Human CellExp™ CD38, Human Recombinant | P1014

CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

P1014 | Human CellExp CD38 human recombinant DataSheet

Biomolecule/Target: CD38

Synonyms: ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10

Alternates names: Apolipoprotein E2, apolipoprotein, apolipoproteins

Taglines: N/A

NCBI Gene ID #: 348

NCBI Gene Symbol: ApoE

Gene Source: Human

Accession #: NM_000041

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: 95% SDS-PAGE

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): The specific (Cyclase) activity is > 10 mU/mg, as measured under the described conditions using ’s CD38 (Cyclase) Activity Assay Kit (Cat. No. K2042).

Biological activity: Test in process

Results: N/A

Binding Capacity: N/A

Unit Definition: One unit is the amount of enzyme that cleaves the substrate nicotinamide guanine dinucleotide (NGD+) and liberates 1 mol MAP per minute at pH 7.5 and 37 °C

Molecular Weight: 34.3 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 µm filtered solution in PBS (pH 7.4) with 5% Trehalose

Reconstitution Instructions: Reconstitute in dHO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A