Human CellExp™ CD62E/E-Selectin, human recombinant | 7434

E-Selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 and TNF. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF- by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.

7434 | Human CellExp CD62E/E-Selectin human recombinant DataSheet

Biomolecule/Target: CD62E/E-Selectin

Synonyms: SELE, RP1-117P20.2, CD62E, ELAM1, ESEL, LECAM2, E-Selectin

Alternates names: Insulin, INS

Taglines: Plays an important part in recruiting leukocytes to the site of injury.

NCBI Gene ID #: 3630

NCBI Gene Symbol: INS

Gene Source: Human

Accession #: P01308

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: The recombinant insulin is fully biologically active when compared to World Health Organization (WHO) reference standard which is 28 units/mg.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 5.81 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution Instructions: Reconstitute in H20 to a concentration of 1.0 mg/ml. The solution can then be diluted to other aqueous buffers.

Amino acid sequence: N/A