Human CellExp™ CD8b, Human Recombinant | P1244

The T-cell surface glycoprotein CD8 beta chain, also called CD8 beta (CD8b), P37 or LEU2 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Being a member of functional coreceptors, CD8 functions either as a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. In T-cells, CD8b functions primarily as a coreceptor for class I MHC molecules. It initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, CD8b plays a critical role in thymic selection of CD8+ T-cells. CD8b is thought to play a role in the process of T-cell mediated killing.

P1244 | Human CellExp CD8b Human Recombinant DataSheet

Biomolecule/Target: CD8b

Synonyms: T cell surface glycoprotein CD8 beta chain, T lymphocyte surface glycoprotein beta chain, CD8b antigen, CD8 antigen beta polypeptide 1 (p37), CD8 beta, CD8b, CD8B_HUMAN, CD8B1, Leu2, Ly3, LYT3, MGC119115, P37

Alternates names: Urokinase, Abbokinase, Urokinase-type Plasminogen Activator,uPA, EC 3.4.21.73, UK.

Taglines: Integral membrane glycoprotein that plays an essential role in the immune response

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #:

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 54.0 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS pH 7.4

Reconstitution Instructions: Reconstitute in sterile HO to a concentration >100 g/ml. The solution can then be diluted into other aqueous solutions.

Amino acid sequence: N/A