Human CellExp™ CSF1R/CD115, Fc Tag, Human Recombinant, | P1374

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

P1374 | Human CellExp CSF1R/CD115 Fc Tag Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR

Alternates names: Thrombospondin-1, THBS1, TSP, TSP1, THBS, THBS-1

Taglines: Plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells.

NCBI Gene ID #: 7057

NCBI Gene Symbol: TSP1

Gene Source: Human

Accession #: P07996

Recombinant: FALSE

Source: HEK293 cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 0.1 EU per g by the LAL method.

Activity (Specifications/test method): Immobilized Human M-CSF, His Tag at 5 g/mL (100 L/well) can bind Human M-CSF R, Fc Tag with a linear range of 0.1-4 ng/mL

Biological activity: N/A

Results: N/A

Binding Capacity: Immobilized Human M-CSF, His Tag at 5 g/mL (100 L/well) can bind Human M-CSF R, Fc Tag with a linear range of 0.1-4 ng/mL

Unit Definition: N/A

Molecular Weight: 180 kDa in reducing Gel

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Liquid

Reconstitution Instructions: Reconstitute with water at the concentration 0.1 mg/ml.

Amino acid sequence: N/A