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Human CellExp™ ECE1, Human Recombinant | P1227

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SKU:
26-P1227-GEN
Availability:
Usually shipped in 5 working days
$1,701.00 - $5,715.50

Description

Endothelin-Converting Enzyme-1 (ECE-1) is a single-pass type II transmembrane (TM) protein with a short cytoplasmic tail and a large ectodomain. ECE-1 is a zinc protease of the neprilysin (NEP) family, which also includes ECE-2, PEX, XCE, DINE, and Kell, and several NEP-like proteins. It is widely expressed and has several alternatively spliced forms that differ in their TM domain or cytoplasmic tail. All isoforms of ECE-1 are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Endothelin-converting enzyme-1 is involved in the proteolytic processing of Endothelin-1 (EDN1), Endothelin-2 (EDN2), and Endothelin-3 (EDN3) to biologically active peptides. Defects in ECE1 are a cause of Hirschsprung disease, cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.

P1227 | Human CellExp ECE1 Human Recombinant DataSheet

Biomolecule/Target: ECE1

Synonyms: Endothelin-converting enzyme 1, ECE-1

Alternates names: Proliferating cell nuclear antigen, PCNA, Cyclin, MGC8367,

Taglines: Converts big endothelin-1 to endothelin-1

NCBI Gene ID #: 5111

NCBI Gene Symbol: PCNA

Gene Source: Human

Accession #: P12004

Recombinant: Yes

Source: HEK 293 cells

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 29.8 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from a 0.2 m filtered solution of PBS, pH7.4

Reconstitution Instructions: N/A

Amino acid sequence: N/A

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Additional Information

Storage:
-20°C
Shipping:
Gel Pack
Shelf Life:
12 months
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