Human CellExp™ Fc gamma RIIB /CD32b, human recombinant | 7388

Receptors for the Fc region of IgG (Fc R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fc RII /CD32 (A, B, and C) and one for mouse Fc RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells down regulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

7388 | Human CellExp Fc gamma RIIB /CD32b human recombinant DataSheet

Biomolecule/Target: Fc gamma RIIB /CD32b

Synonyms: FCGR2B, CD32b, CD32, FCG2, IGFR2, CDw32

Alternates names: Heat Shock Protein 20, HSP20

Taglines: A low affinity receptor for IgG

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #:

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSP-20.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: N/A

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in H20 to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted to other aqueous buffers.

Amino acid sequence: N/A