Human CellExp™ Fc gamma RIIIB /CD16b, human recombinant | 7446

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcRIIIa (CD16a) and FcRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner. CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16b, also known as FCGR3B and FCG3B, is expressed specifically by neutrophils and stimulated eosinophils. CD16b is the low affinity receptor for the Fc region of immunoglobulins gamma. It binds complexed or aggregated IgG and also monomeric IgG. CD16b by itself is not capable of mediating antibody-dependent cytotoxicity and phagocytosis and cannot transduce signals from outside to inside the cell but may do so by associating with cell-specific components. Soluble CD16b has a regulatory role in inflammatory processes and induces the production of pro-inflammatory cytokines.

7446 | Human CellExp Fc gamma RIIIB /CD16b human recombinant DataSheet

Biomolecule/Target: Fc gamma RIIIB /CD16b

Synonyms: FCGR3B, CD16B, FCG3B, FCGR3, FCG3, IGFR3

Alternates names: UbcH2, Ubiquitin conjugating enzyme 2, Ubiquitin conjugating enzyme, UbcH2, Ubiquitin carrier protein H, Ubiquitin-conjugating enzyme E2-20K, Ubiquitin-protein ligase H, Ube2h

Taglines: Involved in activation of the NK cells for Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)

NCBI Gene ID #: 7328

NCBI Gene Symbol: UBE2H

Gene Source: Human

Accession #: P62259

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: Recombinant Human Fc RIIIB / CD16b can bind immobilized Anti-CD20 (Rituximab Cat. No. A1049) coated at 2 g/ml (100 l/well)) with a linear range of 1 - 50 g/ml

Unit Definition: N/A

Molecular Weight: 22.2 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered PBS (pH 7.4) with 5% trehalose.

Reconstitution Instructions: N/A

Amino acid sequence: N/A