Human CellExp™ FCGR3A/CD16a, human recombinant | 7431

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcRIIIa (CD16a) and Fc IIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

7431 | Human CellExp FCGR3A/CD16a human recombinant DataSheet

Biomolecule/Target: FCGR3A/CD16a

Synonyms: FCGR3A, CD16A, FCG3, FCGR3, IGFR3

Alternates names: HSPB8 H11 HMN2 CMT2L DHMN2, E2IG1, HMN2A, HSP22, Heat shock protein -8, -crystallin C chain, Small stress protein-like protein HSP22, E2-induced gene 1 protein, Protein kinase H11, CRYAC,

Taglines: A protein involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody dependent cytotoxicity and clearance of immune complexes.

NCBI Gene ID #: 26353

NCBI Gene Symbol: HSPB8

Gene Source: Human

Accession #: Q9UJY1

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSP-22.

Results: Confirmed

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 22 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution Instructions: Reconstitute in H20 to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted to other aqueous buffers

Amino acid sequence: N/A