Human CellExp™ FLT-3 Ligand, Mouse Recombinant | P1382

FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.

P1382 | Human CellExp FLT-3 Ligand Mouse Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: FLT3LG, FL, FLT3L, Flt3 ligand

Alternates names: UbcH5c, Ubiquitin conjugating enzyme H5c, Ubiquitin conjugating enzyme, Ubiquitin carrier protein D3, Ubiquitin-conjugating enzyme E2(17)KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3

Taglines: A member of a small family of growth factors that stimulate the proliferation of hematopoietic cells

NCBI Gene ID #: 7323

NCBI Gene Symbol: UB2D3

Gene Source: Mouse

Accession #: P61077

Recombinant: FALSE

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per g by the LAL method

Activity (Specifications/test method): Immobilized Mouse Flt-3 Ligand, His Tag at 1 g/mL (100 L/well) can bind Human Flt-3/Flk-2 Fc Chimera with a linear range of 1-5 ng/mL

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 17.0 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: N/A

Amino acid sequence: N/A