Human CellExp™ HDAC6, Human Recombinant, Active | P1265

HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.

P1265 | Human CellExp HDAC6 Human Recombinant Active DataSheet

Biomolecule/Target: HDAC6

Synonyms: HDAC6, HDAC6 protein, recombinant HDAC6, human HDAC6, HDAC, recombinant HDAC, recombinant human HDAC6, r_hu HDAC6, HDAC-6, HDAC-6 protein, recombinant HDAC-6, human HDAC-6, recombinant human HDAC-6, recombinant HDAC-6 protein, human HDAC-6 protein, recombinant human HDAC-6 protein, rh HDAC-6, rh HDAC-6 protein, KIAA0901, JM21, HD6, 10013, Q9UBN7, human cell expressed HDAC6, , human cell expressed HDAC-6, 293HEK

Alternates names: KIAA0901, JM21, HD6

Taglines: Regulates the acetylation status of non-histone substrates

NCBI Gene ID #: 3552

NCBI Gene Symbol: IL1A

Gene Source: Human

Accession #: P01583

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGEs: 98%

Assay: SEC

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Deacetylation activity was determined using GAK(Ac)-AMC, Boc-K(Ac)-AMC and Fluor-de-Lys (RHK-K(Ac)-AMC) substrates.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 131 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.4

Reconstitution Instructions: N/A

Amino acid sequence: N/A