26
Human CellExp™ HDAC8, Human Recombinant, Active | P1266
- SKU:
- 26-P1266-GEN
- Availability:
- Usually shipped in 5 working days
Description
Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).
P1266 | Human CellExp HDAC8 Human Recombinant Active DataSheet
Biomolecule/Target: HDAC8
Synonyms: HDACL1, HD8, Histone Deacetylase 8, CDA07
Alternates names: HDACL1, HD8, Histone Deacetylase 8, CDA07
Taglines: Critical regulator of transcription, cell cycle progression, and developmental events
NCBI Gene ID #: 16175
NCBI Gene Symbol: IL1A
Gene Source: Human
Accession #: Q3U0Y6
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGEs: 98%
Assay: SEC
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Deacetylation activity was determined using the Boc-K(TFA)-AMC substrate.
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 41 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.5
Reconstitution Instructions: N/A
Amino acid sequence: N/A