Human CellExp™ ICOSLG /B7-H2 /CD275, Fc Tag, Human Recombinant | P1384

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

P1384 | Human CellExp ICOSLG /B7-H2 /CD275 Fc Tag Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand

Alternates names: Melanoma-derived growth regulatory protein precursor, Cartilage-derived retinoic acid-sensitive protein, CD-RAP, MIA, Melanoma inhibitory activity protein

Taglines: Ligand for the T-cell-specific cell surface receptor ICOS

NCBI Gene ID #: 8190

NCBI Gene Symbol: MIA

Gene Source: Human

Accession #: Q16674

Recombinant: FALSE

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: Less than 1.0 EU per g by the LAL method.

Activity (Specifications/test method): Immobilized Human ICOS (C136S, C137S) at 5 g/mL (100 L/well) can bind Human B7-H2, Fc Tag with a linear range of 0.3-5 ng/mL

Biological activity: The biological activity is determined by the inhibitory effect on the invasion of Mel In Tumor cells and found active in Mel In assay.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 12.2 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized powder

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A