Human CellExp™IL-2, Human Recombinant | P1385

Interleukin-2 (IL-2) is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. IL-2 is one of the key cytokines for the immune system, tolerance and immunity. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma in cancer immunotherapy with long term disease control. In addition to being used as monotherapy, IL-2 can also be combined with other anticancer immunotherapies, such as adoptive cell transfer, vaccination, and blockade of immune checkpoint inhibitory molecules, such as cytotoxic T lymphocyte-associated antigen 4 and programmed death 1 monoclonal-antibodies as a promising treatment for metastatic cancer.

P1385 | Human CellExpIL-2 Human Recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.

Alternates names: Peroxiredoxin 6, 1-Cys, aiPLA2, AOP2, NSGPx, p29, PRX.

Taglines: A regulator of lymphocyte activities

NCBI Gene ID #: 9588

NCBI Gene Symbol: PRDX6

Gene Source: Human

Accession #: P30041

Recombinant: FALSE

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Specific activity: approximately 95-120 pmole/min/µg.

Results:

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 27.1 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP