Human CellExp™ LAIR1 / CD305, Fc Tag, Mouse Recombinant | P1408

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

P1408 | Human CellExp™ LAIR1 / CD305, Fc Tag, Mouse Recombinant DataSheet

Biomolecule/Target :

Synonyms: LAIR1, CD305

Alternates names: LAIR1, CD305

Taglines: Negative regulator of NK cells, B cells and T cells

NCBI Gene ID #: 52855

NCBI Gene Symbol: Lair1

Gene Source: Mouse

Accession #: Q8BG84-1

Recombinant: True

Source: HEK 293 cells

Purity by SDS-PAGE: >95%

Assay: SDS-PAGE

Purity:

Assay #2:

Endotoxin Level: Less than 0.1 EU per ug by the LAL method.

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Concentration:

Appearance: Lyophilized powder

Physical form description: Lyophilized protein

Reconstitution Instructions: Reconstitute in sterile deionized water to a desired concentration.

Amino acid sequence: AA Gln 22 - Tyr 141

Handling: Centrifuge the vial prior to opening.

Usage: